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JiYong Hwang 1 Article
IgG4-Related Disease with lymphadenopathy Presenting as a Cervical lymph node enlargement
Yeon Seok Choi, SungMin Kim, Jang Sihn Sohn, JiYong Hwang, TaeSoo Chang, Do Yeon Cho
Kosin Med J. 2017;32(2):233-239.   Published online December 29, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.233
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

During the course of evaluation and management of neck masses, consideration for Immunoglobulin G4-related disease (IgG4-RD) should be given. IgG4-RD is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis.

A previously healthy 72-year-old man was referred to our clinic with a 2-month history of left cervical lymph node enlargement without systemic manifestations . A cervical lymph node biopsy was planned because of elevated serum IgG4 levels. Pathological findings showed prominent infiltration of IgG4-postive plasma cells in the lymph node. After steroid therapy, a computed tomography scan revealed a decrease in the cervical lymph node size.

This case illustrates the importance of including IgG4-RD in the differential diagnosis of a cervical lymph node enlargement.


KMJ : Kosin Medical Journal