- Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea?
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Ji Young Park, Su Kyoung Kwon
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Kosin Med J. 2018;33(1):41-50. Published online January 21, 2018
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DOI: https://doi.org/10.7180/kmj.2018.33.1.41
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Abstract
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- Objectives
The American Diabetes Association (ADA) recommends hepatitis-B virusVIruS vaccination for unvaccinated adults with diabetes. However, the Korean Diabetes Association (KDA) did not recommend hepatitis-B vaccination for unvaccinated adults with diabetes. This study was performed to assess the differences in hepatitis-B virus antigen and antibody status between Korean patients with diabetes and those without by using national survey data.
MethodsWe analyzed hepatitis-B virus antigen and antibody status in 9,771 South Korean people from the general population based on the Korean National Health and Nutrition Examination Survey. Diabetes patients were defined as those with a measured fasting plasma glucose over 126 mg/dL or those who had been previously diagnosed with diabetes by other health care centers.
ResultsSubjects with diabetes accounted for 812 (8.3%) among the 9771 study subjects. The prevalence ofhepatitis-B (HBsAg) seropositive subjects was not significantly different (3.9% vs. 4.6%, P = 0.09) between subjects with diabetes and those without. The prevalence of hepatitis-B antibody (HBsAb) positive subjects and unimmunized subjects was not significantly different (55.2% vs. 58.2%, P = 0.09, 40.9% vs. 37.2%, P = 0.09) between the two groups. The prevalence of unimmunized subjects decreased by age (< 20 years 33.3 % vs. 33.0%, 20~29 years 49.1% vs. 41.2%, 30~39 years 41.9% vs. 37.7%, 40~49 years 35.1% vs. 33.5%, 50~59 years 39.0% vs. 38.0%, 60~69 years 41.2% vs. 39.8%, > 70 years 48.5% vs. 42.8%) but was not significantly different between the 2 groups.
ConclusionsFrom this study, we conclude that there are not sufficient grounds to recommend routine hepatitis-B virus vaccination for unvaccinated Korean subjects with diabetes at this point in time in Korea. Further prospective studies will be needed.
- The clinical features and infectious etiologies of acute diarrhea in immunocompromised hosts
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Jin Young Lee, Ye Na Kim, Namho Kim, Kyoung Soon Cho, Ji Young Park
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Kosin Med J. 2017;32(2):191-203. Published online December 29, 2017
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DOI: https://doi.org/10.7180/kmj.2017.32.2.191
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Abstract
PDFPubReader ePub
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Objectives
The acute diarrhea is a common complaint among immunocompromised hosts, and may cause life threatening event. The infectious etiologies vary depending on virus, bacteria, and parasites. The most common etiology of acute gastroenteritis is known as enteric virus in Korea.1 But there are few studies about the infectious etiology of acute gastroenteritis in immunocompromised hosts.23 The aim of this study was to investigate the infectious etiologies of acute diarrhea in immunocompromised hosts.
Methods
Seventy three patients were enrolled prospectively in a university hospital from January 2013 to July 2014. Immunocompromised hosts included above 65-year-old people, patients with chronic diseases, solid organ or stem cell transplants, solid organ malignancies, hematologic malignancies, immunosuppressive or steroid taking patients. The clinical data were collected and stool samples collected during diarrhea were undergone laboratory analysis for enteric viruses and bacterial enteropathogens including Salmonella spp., Shigella spp., and Clostridium difficile.
Results
Fifty five patients were analyzed as follows : above 65 year-old people were 36 cases (66%), previous antibiotic usage was 22 cases (41.5%). 44 cases (81.1%) were admitted to general ward whereas 9 cases to ICU (17%). 41 cases (73.6%) were treated with antibiotics. Positive C. difficile toxin assays were 6 cases (11.9%). Other infectious etiologies were not found.
Conclusions
C. difficile infection was more common infectious etiology while enteric viruses and other bacteria are not associated with acute diarrhea among immunocompromised hosts in this study. So C. difficile infection must be considered preferentially in immunocompromised hosts with acute diarrhea.
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Citations
Citations to this article as recorded by
- Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran
Shokouh Yasaie, Seyed Dawood Mousavi Nasab, Saeed Shams, Atousa Ferdousi, Hooman Kaghazian Infection Prevention in Practice.2024; 6(3): 100370. CrossRef - Prevalence of Human Adenovirus, Epstein-Barr Virus, and Cytomegalovirus in Pediatric Hematologic Diseases in Iran
Shokouh Yasaie, Atousa Ferdousi, Seyed Dawood Mousavi Nasab, Hooman Kaghazian, Saeed Shams Infection Epidemiology and Microbiology.2024; 10(1): 51. CrossRef - Mucoprotectants
Sung Eun Kim The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(2): 108. CrossRef
- Case of subdural Empyema Secondary to Suppurative Otitis Media
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So Young Huh, Ji Hyun Lee, Ji Young Park
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Kosin Med J. 2009;24(1):187-189. Published online June 30, 2009
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