- Exploring the influence of olfactory receptors in metabolic diseases and cancers: beyond sensory functions
-
In-sun Yu, Jeong Sook Ye, Jaewon Shim
-
Kosin Med J. 2025;40(1):15-20. Published online February 17, 2025
-
DOI: https://doi.org/10.7180/kmj.24.142
-
-
 Abstract
 PDF PubReader  ePub
- Olfactory receptors (ORs), which are primarily responsible for olfactory sensation in the nasal epithelium, constitute the largest family of genes in the human genome. The majority of ORs are orphan receptors with unknown ligands; however, recent studies have revealed their expression in non-olfactory tissues, implying that ORs may be involved in various physiological processes beyond olfaction. This review highlights recent findings on the roles of ORs in cancers, including prostate, breast, and lung cancer, as well as their involvement in other diseases, such as atherosclerosis, Alzheimer's disease, and viral infections. Additionally, we explore emerging knowledge about the role of ORs in metabolic regulation, focusing on their effect on triglyceride metabolism, glucagon-like peptide-1 secretion, and lipid accumulation. Advancements in technology, such as structural analysis, have accelerated research on OR ligands and their functions, potentially positioning ORs as novel therapeutic targets for various diseases. This review highlights the need for further research into the non-olfactory roles of ORs and their potential as targets for future therapeutic interventions.
- Considerations for experimental animal ethics in the research planning and evaluation process
-
Jaewon Shim, Jeongtae Kim
-
Kosin Med J. 2022;37(4):271-277. Published online December 22, 2022
-
DOI: https://doi.org/10.7180/kmj.22.139
-
-
19,163
View
-
449
Download
-
5
Citations
-
Abstract
PDFPubReader ePub
- Research using experimental animals has substantially contributed to advances in science and medicine. Animal experiments are nearly essential for biomedical research and development efforts. Because many animals are sacrificed, researchers should consider the welfare of experimental animals and related ethical issues, along with the successful results of their experiments. This review introduces the criteria that should be considered in terms of experimental animal ethics, based on the principles of the 3 R’s: replacement, representing careful consideration of the need for animal experiments; reduction, representing the use of the minimal number of animals to obtain meaningful experimental results; and refinement, representing continuous effects to find alternative methods to reduce pain and distress in experimental animals. Based on these principles, the following points should be considered when planning experiments: the necessity of animal experiments; alternatives to animal experiments; the relevance of the species and numbers of experimental animals; appropriate assessment and management of pain; the proper usage of sedatives, painkillers, and anesthesia; and valid timing for humane endpoints and euthanasia. These criteria are beneficial for both experimental animals and researchers because careful handling to ensure experimental animal welfare guarantees that scientific research will yield convincing, repeatable, and accurate results.
-
Citations
Citations to this article as recorded by  - Relevant Species Selection for Preclinical Safety Studies of Medicines: A Review
G. N. Engalycheva, R. D. Syubaev
Safety and Risk of Pharmacotherapy.2025; 13(1): 31. CrossRef - Aspectos éticos da biossegurança e experimentação animal
Thais Ferreira Costa dos Santos, Maria Angélica de Sousa Vieira, Sara Brito Rebouças Araújo, Patrick Assunção Mourão, Maylla Rodrigues Lucena, Matheus Silva Alves, Arannadia Barbosa Silva, Ermilton Junio Pereira de Freitas, Anivaldo Pereira Duarte Junior
Caderno Pedagógico.2025; 22(5): e14871. CrossRef - Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
Eun-Ji Ko, Do-Ye Kim, Min-Hye Kim, Hyojin An, Jeongtae Kim, Jee-Yeong Jeong, Kyoung Seob Song, Hee-Jae Cha
International Journal of Molecular Sciences.2024; 25(2): 833. CrossRef - General Principles, Designs, and Statistical Analyses in Experimental Animal Studies
Şengül Cangür
Düzce Tıp Fakültesi Dergisi.2024; 26(S1): 14. CrossRef - Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses
Megan Caifeng Tang, Ka Heng Wong, Adzzie Shazleen Azman, Rafidah Lani
Animal Models and Experimental Medicine.2024; 7(5): 673. CrossRef
|
KOSIN UNIVERSITY COLLEGE OF MEDICINE
