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Heung Yeol Kim 29 Articles
Oxidative stress and endometriosis
Yeon Jean Cho, Heung Yeol Kim
Kosin Med J. 2018;33(2):135-140.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.2.135
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period and is associated with pelvic pain and infertility. Oxidative stress (OS) occurs when reactive oxygen stress (ROS) and anti-oxidants are in imbalance. OS is a potential factor involved in the pathophysiology of endometriosis. Iron-induced ROS may trigger a chain of events resulting in the development and progression of endometriosis. Endogenous ROS are correlated with increased cellular proliferation and ERK1/2 activation in human endometriotic cells. An oxidative environment leads to stimulation of the ERK and PI3K/AKT/mTOR signaling pathways that facilitate endometriotic lesion progression through adhesion, angiogenesis, and proliferation. OS is also known to be involved in epigenetic mechanisms in endometriosis. We summarize the recent knowledge in our understanding of the role of oxidative stress in the pathogenesis of endometriosis.

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  • Zingiber officinale Roscoe (Ginger) as a Complementary Option for Clinical Treatment of Endometriosis: An Experimental Study in Rats
    José Meneses de Morais Filho, João Nogueira Neto, Lyvia Maria Rodrigues de Sousa Gomes, Izabelle Smith Frazão Ramos, Salie Santos Rodrigues Oliveira, George Castro F. Melo, Lucilene Amorim Silva, Ed Carlos Rey Moura, Plínio da Cunha Leal
    Journal of Medicinal Food.2021; 24(4): 342.     CrossRef
What to do with troublesome hot flush?
Su Hyun Chae, Chulmin Lee, Heung Yeol Kim, Ji Young Lee
Kosin Med J. 2018;33(2):141-149.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.2.141
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Hot flush (hot flush or facial flush) is the most frequent symptom experienced by women of peri-menopausal age. It may appear on women or even men after surgery or chemotherapy. Hot flush is one of the biggest reason for women to undergo hormone replacement therapy (HRT). It also crucially affects various aspects of life quality such as occupation, social life, daily routine and health awareness. The most effective and fundamental remedy for hot flush is HRT. However, a few women is not responsive to HRT and investigation to elucidate other causes of hot flush is warranted, especially in elderly. The contraindications such as breast cancer mandates other modality of treatment. Variety of treatment for hot flush other than HRT will be discussed herein.

The Role of Vitamin D in Menopausal Medicine
Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
Kosin Med J. 2016;31(2):97-102.   Published online January 20, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.2.97
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Abstract

Menopause is the time at which menstruation stops in women. After menopause, women are more susceptible to some diseases, especially osteoporosis and cardiovascular disease. Vitamin D has a protective effect against osteoporosis by facilitating the absorption of calcium and affecting parathyroid hormone. Vitamin D also affects cardiovascular function by lowering the blood pressure, which affects the renin–angiotensin system and alters the low-density lipoprotein receptor activity. This paper discusses supplemental vitamin D in postmenopausal women with osteoporosis and cardiovascular disease.

Uterine cancer and ezrin expression
Yeon-Suk Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Dahyae Jang, Arum Lee
Kosin Med J. 2016;31(1):5-10.   Published online September 16, 2015
DOI: https://doi.org/10.7180/kmj.2016.31.1.5
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Abstract

Today, almost 20% of female cancers are gynecological in nature. In particular, uterine cervical cancer and endometrial cancer (which have been intensively studied) seriously compromise female health. One of the ezrin-radixin-moesin (ERM) proteins, ezrin, has been associated with cancer in prior studies, including the two cancers mentioned above. Ezrin expression increases, as does the expression of other factors, in uterine cervical cancer; ezrin may promote cancer development by influencing the actions of the other factors. Also, an increase in ezrin level contributes to the development of diseases such as endometrial cancer.

Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
Kosin Med J. 2015;30(2):103-107.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.103
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Abstract

Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.

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  • The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
    Rui Guo, Yu Chen, Heather Borgard, Mayumi Jijiwa, Masaki Nasu, Min He, Youping Deng
    Molecules.2020; 25(20): 4864.     CrossRef
  • Plasma metabolites as possible biomarkers for diagnosis of breast cancer
    Jiwon Park, Yumi Shin, Tae Hyun Kim, Dong-Hyun Kim, Anbok Lee, Mohana Krishna Reddy Mudiam
    PLOS ONE.2019; 14(12): e0225129.     CrossRef
Comparative Study of an Ondansetron and a Ramosetron an Aprepitant in the Control of Nausea and Vomiting in Gynecologinc Cancer Patient with Chemotherapy
HANGGOO Yun, Heung Yeol Kim, Eun ae Jeh
Kosin Med J. 2013;28(2):115-121.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.115
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Results

The efficacy of controlling nausea with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen was 85.29%, 78.26%, 80% in acute periods (P-value = 0.037) and 88.23%, 98.26%, 87.5% in delayed periods (P-value = 0.000), respectively. The efficacy of controlling vomiting with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen and an ondansetron regimen was 82.35%, 97.3%, 90% in acute periods (P-value=0.002) and 82.35%, 100%, 95% in delayed periods (P-value = 0.000), respectively. The common adverse effects in each groups were not significantly.

Conclusions

Appropriate to each patient’s symptoms, the choice of drugs will be needed since each of the drugs have different effects on vomiting. Even though the each antiemetic drug has good efficacy, the effect of the drug is not complete. Therefore the use of additional drugs are also needed.

Objectives

Chemotherapy induced nausea and vomiting is most distressing adversed effects in gynecologic cancer patients receiving chemotherapy. we compared effectiveness of ondansetron and ramosetron and aprepitant for optimal antiemetic treatment in gynecologic cancer patient receiving chemotherapy.

Methods

The study was performed retrospective on 189 patients who was diagnosed initially the gynecological cancer during chemotherapy at Kosin university hospital between January 2008 and December 2010. The efficacy of controlling acute/delayed nausea and vomiting were analyzed by counting numbers of nausea and vomiting reported in medical records of 189 patient receiving cisplatin-based chemotherapy. Statistical analysis was performed using the ANOVA and Fisher’s exact chi-square test.

Results

The efficacy of controlling nausea with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen was 85.29%, 78.26%, 80% in acute periods (P-value = 0.037) and 88.23%, 98.26%, 87.5% in delayed periods (P-value = 0.000), respectively. The efficacy of controlling vomiting with an ondansetron regimen and a ramosetron regimen and an aprepitant regimen and an ondansetron regimen was 82.35%, 97.3%, 90% in acute periods (P-value=0.002) and 82.35%, 100%, 95% in delayed periods (P-value = 0.000), respectively. The common adverse effects in each groups were not significantly.

Conclusions

Appropriate to each patient’s symptoms, the choice of drugs will be needed since each of the drugs have different effects on vomiting. Even though the each antiemetic drug has good efficacy, the effect of the drug is not complete. Therefore the use of additional drugs are also needed.

The Association Between Serum GGT Level and Bone Mineral Density in Postmenopausal Women
Heung Yeol Kim, Eun Hee Kong
Kosin Med J. 2013;28(1):35-41.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.1.35
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Objectives

The aim of this study was to identify the relationship between serum gamma-glutamyltransferase (GGT) and bone mineral density (BMD) in postmenopausal women.

Methods

We evaluated 200 postmenopausal women who were visiting a health promotion center at a university hospital from January 2009 to December 2011. Their current medical diseases and medication history were collected through medical records. Basic physical examinations and laboratory tests were performed on all subjects.

Results

The levels of serum GGT within their normal range were positively correlated with waist circumference (P = 0.01), triglycerides (P <0.001), alkaline phosphatase (P = 0.009), and uric acid (P = 0.01). The serum GGT within their normal range were negatively associated with the femur neck BMD (P = 0.002). In adjusted analysis including age and body mass index, the BMD of the femur neck was more strongly associated with a high-normal serum GGT level among the postmenopausal women as compared with those with a low-normal serum GGT level (P = 0.02).

Conclusions

Serum GGT within its normal range is negatively correlated with the BMD in the femur neck among postmenopausal women. It can be useful for selecting a group that is at high risk for the bone fracture regardless of the underlying mechanism.

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  • The Role of Vitamin D in Menopausal Medicine
    Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
    Kosin Medical Journal.2016; 31(2): 97.     CrossRef
  • The Role of Vitamin D in Menopausal Medicine
    Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
    Kosin Medical Journal.2016; 31(2): 97.     CrossRef
Nutritional Treatment: New Strategy for Management of Chronic Pelvic Pain
Jong Soon Choi, Heung Yeol Kim
Kosin Med J. 2013;28(1):7-12.   Published online August 17, 2012
DOI: https://doi.org/10.7180/kmj.2013.28.1.7
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Chronic pelvic pain is a common condition in women of reproductive age and can be described as chronic nociceptive, inflammatory and neuropathic pain characterized by spontaneous pain or a response to various stimuli. Oxidative stress is a component of the inflammatory reaction associated with pain processes. Iron and NF-κB are well-known inducers of oxidative stress, and reactive oxygen species (ROS) are associated with chronic pelvic pain and play an important role in the regulation of genes expressing immunoregulators, cytokines, and other molecules. Chronic pelvic pain treatment is often unsatisfactory and limited to symptom control. However, dietary treatment with antioxidants can improve the function of the immune system and overcome free radical damage. Therefore, dietary supplementation is suggested as a means to treat some chronic medical conditions that respond poorly to medication. In summary, dietary treatment with antioxidants could be considered for new strategy for treatment of chronic pelvic pain and may be better tolerated by patients than current treatments.

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  • Medical and social aspects in women of reproductive age with chronic pelvic pain
    S.О. Shurpyak, O.B. Solomko
    Reproductive health of woman.2021; (6): 71.     CrossRef
The Effectiveness of Medical Communication Skill of Medical Students, through an Emphasis on Role Play
Ho Seob Lihm, Heung Yeol Kim, Jong Soon Choi
Kosin Med J. 2012;27(2):151-159.   Published online December 27, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.2.151
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

Medical doctors require outstanding communication skills when meeting with their patients. Thus medical student need to education and training about medical communication skill. More attention is being given to the subject but not many studies have been done in the medical education field. As communication skills are provided to students as a subject in medical educational curriculum, the assessment of its effectiveness needs to be undertaken.

Methods

In the year 2010 and 2011, first-year medical students at The Kosin University College of Medicine took 'Communication skills' course in total, 154 first-year medical students survey results was the modified and translated version of 'Beyer-Fetzer's Essential Elements of Communication Skills Assessment Sheet'. The assessment sheets were used as the pre-test and post-test to analyse the differences, which were put through the paired t-test.

Results

All categories of communication skills showed an improvement. For year 2010, a statistically significant difference was shown into the 22 questions, whereas in 2011, improvements were shown in all questions.

Conclusions

From the result, it is clear that in order to create an effective communication skills program, the content should be more structured and focused on the program objectives.

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  • The Modified Brief-Structured Observation is Helpful to Understand Students’ Clinical Reasoning Process
    황영은, 서지현, 우향옥, Hee-Shang Youn, HwaokBae, 박정제, 윤인애, 강기련
    Health Communication, the Official Journal of Korean Academy on Communication in Healthcare.2016; 11(1): 1.     CrossRef
  • Curriculum Integration of Communication Simulation to Community Health Nursing Course for Nursing Students: Pilot Study
    Yi-Kyung Ha
    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(4): 2329.     CrossRef
Predictive Value of Maternal Serum Markers for Preeclampsia
Sue Hyun Oh, Heung Yeol Kim
Kosin Med J. 2012;27(2):91-97.   Published online January 19, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.2.91
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The study performed a systematic review of screening for preeclampsia with the combination of vascular parameters and maternal serum markers in the first and early second trimester. We identified eligible studies through a search of Medline, and, for each included study, we focused on the relationship between the maternal serum markers and preeclampsia. In the selected literature, a combination of maternal serum markers was analyzed, also. Several tests suggested moderate or convincing prediction of early preeclampsia, but screening for late preeclampsia was poor. Literatures for serum markers were selected. Each serum marker was identified independently, and where relevant, a combination of these markers was analyzed. Encouraging results for the first trimester screening were observed when it was combined with other markers. Even in the first trimester of pregnancy, we can present the reliable results for the prediction of early preeclampsia. Detection rate for combination markers may yield higher detection rate and be promising to identify patients at high risk of developing preeclampsia.

Recent Trends in Chronic Pelvic Pain Diagnosis
Ari Kim, Heung Yeol Kim
Kosin Med J. 2012;27(1):11-16.   Published online June 11, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.1.11
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Chronic pelvic pain is a common and significant disorder of women. It is estimated to have a prevalence of 3.8% in women. The etiology of chronic pelvic pain in women is poorly understood. Although a specific diagnosis is not found in the majority of cases, some common diagnoses include endometriosis, adhesions, irritable bowel syndrome, and interstitial cystitis. The initial history and physical examination can narrow the diagnostic possibilities, guide any subsequent evaluation, and rule out malignancy or significant systemic disease. If the initial evaluation does not reveal a specific diagnosis, a limited laboratory and ultrasound evaluation can clarify the diagnosis, as well as rule out serious disease and reassure the patient.

Laboratory and imaging studies should be selectively utilized, as should laparoscopy. Conscious laparoscopic pain mapping has been proposed as a way to improve information derived from laparoscopic evaluations.

Diagnosis and Treatment of Osteoporosis
Khunying Kobchitt Limpaphayom, Heung Yeol Kim
Kosin Med J. 2011;26(2):121-126.   Published online December 1, 2011
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A survey of Attitude Toward Sex of College Girls in Busan
Young Lim Oh, Heung Yeol Kim
Kosin Med J. 2009;24(2):14-19.   Published online December 31, 2009
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Histologic Appearance According to Endometrial Thickness in Postmenopause Endometrial Fluid Accumulation Women
Heung Yeol Kim, Hong Bae Kim, Wan Kyu Eo
Kosin Med J. 2008;23(2):44-47.   Published online June 30, 2008
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Small Cell Carcinoma of the Uterine Cervix : a Clinical Characteristics and Prognostic Factors of the 4 Cases
Young Lim Oh, Heung Yeol Kim, Wan Kyu Eo, Hong Bae Kim
Kosin Med J. 2008;23(2):48-51.   Published online June 30, 2008
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Two Cases of Juvenile Granulosa Cell Tumor of Ovary
Wan Kyo Eo, Heung Yeol Kim, Hong Bae Kim
Kosin Med J. 2008;23(2):110-114.   Published online June 30, 2008
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Clinical Comparison of Laparoscopically Assisted Vaginal Hysterectomy and Total Vaginal Hysterectomy
Jong Yeol Choi, Chun Jun Lee, Heung Yeol Kim
Kosin Med J. 2007;22(2):63-70.   Published online December 31, 2007
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Clinical Evaluation of 80 Cases of Laparoscopically Assisted Vaginal Hysterectomy (LAVH)
Young Lim Oh, Heung Yeol Kim
Kosin Med J. 2007;22(1):93-98.   Published online June 30, 2007
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The Relationship Between Initial Biochemical Bone Markers and Change of Bone Mineral Density in Post Menopausal Women with Hormone Therapy
Chi Heui Cho, Eun Hee Kong, Young Sik Choi, Yang Soo Kim, Heung Yeol Kim, Wan Kyu Eo, Ki Yeon Hong
Kosin Med J. 2007;22(1):212-219.   Published online June 30, 2007
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The Effect of Apoptosis Related Protein Expression by Cyclosporine in Osteoblast
Young Lim Oh, Wan Kyu Eo, Ki Yeon Hong, Yang Soo Kim, Heung Yeol Kim
Kosin Med J. 2007;22(1):232-239.   Published online June 30, 2007
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A Case of Vaginal Evisceration after Laparoscopic Hysterectomy
Young Lim Oh, Heung Yeol Kim
Kosin Med J. 2007;22(1):256-258.   Published online June 30, 2007
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The Effect of Bone in Primary Osteoporosis Treatment of Bisphosphonate
Young Lim Oh, WAN KYU EO, Young Sik Choi, HEUNG YEOL KIM
Kosin Med J. 2006;21(2):37-40.
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A Case of Pelvic Actinomycosis Simulating Ovarian Cancer
Young Lim Oh, HEUNG YEOL KIM
Kosin Med J. 2006;21(2):158-161.
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Significance of Squamous Cell Carcinoma Antigen in Invasive Cervical Carcinoma
Ja Young Seo, Young Il Nam, In Cheol Lee, Young Lim Oh, Tae Wha Lee, Un Dong Park, Heung Yeol Kim, Sung Do Yoon
Kosin Med J. 2003;18(1):87-92.
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The effects of Hormon Replacement Therapy & 1α-hydroxyvitamin D3 on the Bone Mineral Density and Bone turn over markers in menopausal women
Dong Whee Cho, Sung Hwan Jo, Wan Kyu Eo, Heung Yeol Kim
Kosin Med J. 2003;18(1):142-151.
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Effect of GnRH agoinst Treatment on Leiomyoma -A study on the clinical effect and ultrastructural changes-
Heung Yeol Kim, Un Dong Park, Hee Kyung Chang, Man Ha Huh
The Journal of Kosin Medical College. 1993;9(1):71-80.
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A Clinical Study of 12 Cases of Uterine Sarcoma
Heung Yeol Kim, Un Dong Park
The Journal of Kosin Medical College. 1992;8(2):197-206.
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KMJ : Kosin Medical Journal