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Hee-Shang Youn 2 Articles
Clinical features of Epstein-Barr Virus-associated Infectious Mononucleosis According to Age Group in Children
Soram Lee, Ju-Young Chung, Jung Je Park, Ji-Hyun Seo, Jae Young Kim, Jung Sook Yeom, Eun-Sil Park, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Kosin Med J. 2018;33(3):347-357.   Published online January 19, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.3.347
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Abstract PDFPubReader   CrossRef-TDMCrossref - TDM
Objectives

Few studies of pediatric Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM) have been conducted in Korea. We evaluated the clinical features of children with IM to define differences according to age.

Methods

We conducted retrospective chart reviews of 68 children aged 0 to 15 years who were diagnosed by EBV-associated IM with EBV-Viral Capsid Antigen(VCA) IgM at laboratory test and were admitted between 2010 and 2014. The children were classified into four age groups: aged 0–3, 4–6, 7–9, and 10–15 years.

Results

The age distribution of patients was as follows: 19 (27.9%) 0–3, 25 (36.8%) 4–6, 13 (19.1%) 7–9, and 11 (16.2%) 10–15. Fever was the most common presentation regardless of age. It was more common in the 0–3 group than the 4–6 group (P = 0.018). Pharyngitis was more common in the 7–9 group than the 0–3 group (P = 0.048), and myalgia was more common in the 10–15 group than the 0–3 group (P = 0.007). Pharyngitis was accompanied by lymphadenopathy, protracted fever, and rash. In the 0–3 age group, the prevalence of rash was higher while the percentage of atypical lymphocytes was lower, but there was no statistical support for this tendency. There were no differences in the frequency of hepatosplenomegaly or laboratory findings between age groups.

Conclusions

IM is not uncommon in young children and its clinical presentation varies with age. Therefore, IM should be suspected in young febrile children with pharyngitis and rash despite low percentages of atypical lymphocytes.

Citations

Citations to this article as recorded by  
  • The Nature and Clinical Significance of Atypical Mononuclear Cells in Infectious Mononucleosis Caused by the Epstein-Barr Virus in Children
    Olga S Fedyanina, Anna E Filippova, Olga I Demina, Olga A Zhuliabina, Dmitry S Tikhomirov, Alexander V Filatov, Tatiana A Chebotareva, Sofya A Kuznetsova
    The Journal of Infectious Diseases.2021; 223(10): 1699.     CrossRef
Comparative study between an intensive small group teaching and a 1-year clinical practice on OSCE
Sinjae Kim, Minhwan Park, Ji-Hyun Seo, Hyang-Ok Woo, Hee-Shang Youn, Jung Je Park, Sea-Yuoug Jeon, Jung Seok Hwa, Patricia Mullan, Larry D. Gruppen
Kosin Med J. 2018;33(2):181-190.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.2.181
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

Our school introduced a new curriculum based on faculty-directed, intensive, small-group teaching of clinical skills in the third-year medical students. To examine its effects, we compared the mean scores on an OSCE between the third- and fourth-year medical students.

Methods

Third- and fourth-year students did rotations at the same five OSCE stations. They then completed a brief self-reporting questionnaire survey to examine the degree of satisfaction with new curriculum in the third-year students and clinical practice in the fourth-year students, as well as their perception of confidence and preparedness. We analyzed the OSCE data obtained from 158 students, 133 of whom also completed the questionnaire.

Results

Mean OSCE scores on the breast examination and wet smear stations were significantly higher in the third-year group (P < 0.001). But mean OSCE scores of motor-sensory examination and lumbar puncture were significantly higher in the fourth-year group (P < 0.05). The mean OSCE scores had no significant correlation with satisfaction. In addition, the self-ratings of confidence had a high degree of correlation with satisfaction with new curriculum (r = 0.673) and clinical practice (r = 0.692). Furthermore, there was a moderate degree of correlation between satisfaction and preparedness in both groups (r = 0.403 and 0.449).

Conclusions

There is no significant difference in the effect on the degree of clinical performance and confidence between an intensive-small group teaching and a 1-year clinical practice. If combined, intensive small group teaching and clinical practice would be useful to improve the degree of ability and confidence in medical students.


KMJ : Kosin Medical Journal