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Hae Won Lee 4 Articles
Diagnostic value of BRAFV600E mutation analysis in fine needle aspiration for evaluation of thyroid nodules
Hae Won Lee, So Young Ock, Bu Kyoung Kim, Su Kyoung Kwon, Young Sik Choi, Jeong Hoon Kim, Sang Bong Jung
Kosin Med J. 2018;33(1):1-11.   Published online January 21, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.1.1
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Abstract PDFPubReader   CrossRef-TDMCrossref - TDM
Objectives

Ultrasound-guided fine-needle aspiration (FNA) is routinely used in the evaluation of thyroid nodules. However, it has several pitfalls, as has been noted in nondiagnostic and indeterminate cases. This study aims to investigate the value of BRAFV600E mutation co-testing in FNA cytology.

Method

A total of 310 patients underwent BRAFV600E mutation co-testing in FNA cytology on thyroid nodules between June 2013 and June 2014. Of the 310 patients, 69 patients who had undergone a surgery for thyroid nodules were included in this study. The presence of the BRAFV600E mutation was determined by allele-specific polymerase chain reaction amplification of exon 15 of the BRAF gene.

Results

Of 69 cases, 33 (47.8%) were BRAFV600E mutation positive. The BRAFV600E mutation was not significantly associated with high-risk features such as tumor size, lymph node metastasis, and pathological stage. The respective diagnostic performance of FNA (P = 0.02), BRAFV600E mutation (P = 0.03), and ultrasonographic (P = 0.00) findings was statistically significant. The sensitivity, specificity and positive predictive value of FNA was 64.9%, 83.3%, and 94.8%. The sensitivity, specificity and positive predictive value of BRAFV600E mutation was 56.1%, 91.7%, and 96.9% and the US features was 91.2%, 91.7%, and 98.1% respectively. However, sensitivity of FNA with BRAFV600E mutation (77.2%) was lower than FNA with US (92.9%) and combination all together (92.9%).

Conclusion

In this study, we found that US features were the most useful in preoperative differential diagnosis of thyroid nodules. BRAFV600E mutation co-testing in FNA cytology was also useful for diagnosis of thyroid tumors.

A Case of Reactivation of Hepatitis B and Fulminant Hepatitis which developed 3 months following Chemotherapy Including Rituximab in a Patient with Lymphoma
Tae Won Lim, Hee Taek Oh, Seung Un Song, Hae Won Lee, Ji Yeon Kim, Seon Ja Park
Kosin Med J. 2014;29(2):161-168.   Published online December 18, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.2.161
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Abstract PDFPubReader   CrossRef-TDMCrossref - TDM
Abstract

Since Wands et al. reported for the first time in 1975 the reactivation of the hepatitis B virus in hematologic disease patients who had been receiving chemotherapy, the efficacy of chemotherapy and immunosuppressants has improved. As a result, the frequency of the reactivation of hepatitis B is increasing. Reported herein is a case of a non-Hodgkin lymphoma patient in her 70s who was suspected to have had HBsAg negative/anti-HBs negative occult HBV infection. The patient experienced fulminant hepatitis caused by the reactivation of hepatitis B, and died three months after the R-CHOP regimen was completed. In the HBsAg negative plus HBV DNA-negative case, there were few instances of viral activation of HBV. In this case, antiviral therapy was needed when the patient was confirmed to have become HBV DNA positive through regular monitoring, but its necessity is often overlooked, unlike the preemptive antiviral treatment in the HBsAg positive cases.

A Case of Tracheobronchopathia Osteochondroplastica Diagnosed by Endobronchial Ultrasonography
Cheun Woo Lee, Chul Ho Oak, Man Hong Jung, Man Hong Jung, Tae Won Jang, Seung Kyeong Lim, Eun Ju Cho, Shin Jun Lee, Hae Won Lee, San Geon Gwoo, Bong Kwon Chun
Kosin Med J. 2011;26(2):197-201.   Published online December 1, 2011
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Active Tuberculosis Occurred in Rheumatoid Arthritis Patient Who is Treated with Etanercept after Antituberculosis Chemoprophylaxis with Rifampin
Hae Won Lee, Tae Hwa Lee, Geun-Tae Kim
Kosin Med J. 2010;25(2):203-207.   Published online December 31, 2010
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KMJ : Kosin Medical Journal