- Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
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Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
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Kosin Med J. 2015;30(1):41-49. Published online January 20, 2015
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DOI: https://doi.org/10.7180/kmj.2015.30.1.41
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- Abstract
Objective
The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.
Methods
In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.
Results
AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.
Conclusion
AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.
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- The Association Between Serum GGT Level and Bone Mineral Density in Postmenopausal Women
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Heung Yeol Kim, Eun Hee Kong
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Kosin Med J. 2013;28(1):35-41. Published online January 19, 2013
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DOI: https://doi.org/10.7180/kmj.2013.28.1.35
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The aim of this study was to identify the relationship between serum gamma-glutamyltransferase (GGT) and bone mineral density (BMD) in postmenopausal women.
MethodsWe evaluated 200 postmenopausal women who were visiting a health promotion center at a university hospital from January 2009 to December 2011. Their current medical diseases and medication history were collected through medical records. Basic physical examinations and laboratory tests were performed on all subjects.
ResultsThe levels of serum GGT within their normal range were positively correlated with waist circumference (P = 0.01), triglycerides (P <0.001), alkaline phosphatase (P = 0.009), and uric acid (P = 0.01). The serum GGT within their normal range were negatively associated with the femur neck BMD (P = 0.002). In adjusted analysis including age and body mass index, the BMD of the femur neck was more strongly associated with a high-normal serum GGT level among the postmenopausal women as compared with those with a low-normal serum GGT level (P = 0.02).
ConclusionsSerum GGT within its normal range is negatively correlated with the BMD in the femur neck among postmenopausal women. It can be useful for selecting a group that is at high risk for the bone fracture regardless of the underlying mechanism.
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Citations
Citations to this article as recorded by - The Role of Vitamin D in Menopausal Medicine
Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
Kosin Medical Journal.2016; 31(2): 97. CrossRef - The Role of Vitamin D in Menopausal Medicine
Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
Kosin Medical Journal.2016; 31(2): 97. CrossRef
- Various Diet on Immune and Nutrition of Gastrointestinal Surgical Patients
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Eun Hee Kong
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Kosin Med J. 2011;26(2):127-133. Published online December 1, 2011
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- Regulation of Piplartine on Apoptotic Death of Human Prostate Cancer Cells: Based on Microarray
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Eun Hee Kong, Kwang Youn Kim, Sun Nyoung Yu, Sun Yi Lee, Soon Cheol Ann
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Kosin Med J. 2010;25(2):117-122. Published online December 31, 2010
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- Relationship with Metabolic Syndrome by Grade of Nonalcoholic Fatty Livers
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Eun Hee Kong
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Kosin Med J. 2009;24(2):103-108. Published online December 31, 2009
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- The Awarness Regarding Hypertension: Comparision of Hypertensive and Non-Hypertensive
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Eun Hee Kong, Jong Soon Choi
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Kosin Med J. 2008;23(4):137-142. Published online December 31, 2008
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- Development of Nutrition Screening Program for Hospital Inpatients
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Su Mi Ahn, Ki Young Yoon, Yeon Myeong Sin, Kyung Hyun Choi, Geun Seung Lim, Moon Kyung Jang, Yun-Mi Song, Eun Hee Kong
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Kosin Med J. 2008;23(2):29-35. Published online June 30, 2008
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- Health Literacy Regarding Educational Materials on Hypertension
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Eun Hee Kong, Jong Soon Choi
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Kosin Med J. 2007;22(1):81-88. Published online June 30, 2007
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- The Relationship Between Initial Biochemical Bone Markers and Change of Bone Mineral Density in Post Menopausal Women with Hormone Therapy
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Chi Heui Cho, Eun Hee Kong, Young Sik Choi, Yang Soo Kim, Heung Yeol Kim, Wan Kyu Eo, Ki Yeon Hong
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Kosin Med J. 2007;22(1):212-219. Published online June 30, 2007
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