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Eun Hee Kong 14 Articles
Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
Kosin Med J. 2015;30(1):41-49.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.41
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  • 4 Download
  • 13 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract Objective

The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.

Methods

In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.

Results

AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.

Conclusion

AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.

Citations

Citations to this article as recorded by  
  • Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats
    Suzan A. Khodir, Manar A. Faried, Huda I. Abd-Elhafiz, Eman M. Sweed, Krzysztof Siemianowicz
    BioMed Research International.2022; 2022: 1.     CrossRef
  • Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
    Mohammed Alorabi, Doha Saad Mohammed, Gomaa Mostafa-Hedeab, Suzy A. El-Sherbeni, Walaa A. Negm, Ali Ismail A. Mohammed, Hayder M. Al-kuraishy, Nani Nasreldin, Saqer S. Alotaibi, Bashir Lawal, Gaber El-Saber Batiha, Carlos Adam Conte-Junior, Valeria Pasciu
    BioMed Research International.2022; 2022: 1.     CrossRef
  • STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
    Cheol Hong Kim, Kyoung Seob Song
    Kosin Medical Journal.2022; 37(2): 134.     CrossRef
  • Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
    Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
    Journal of Functional Foods.2022; 99: 105303.     CrossRef
  • Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
    Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Antioxidants.2022; 11(10): 1993.     CrossRef
  • The Effect of Ascorbic Acid on Interleukin-10 and Tumor Necrosis Factor-α Cytokines in Rattus norvegicus with Endometritis
    Muhammad Oky Prabudi, M. F. G. Siregar, I. P. A. Nasution, S. Ilyas
    Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798.     CrossRef
  • Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
    Shilpa Bhandi, Ahmed Alkahtani, Mohammed Mashyakhy, Abdulaziz S. Abumelha, Nassreen Hassan Mohammad Albar, Apathsakayan Renugalakshmi, Mazen F. Alkahtany, Ali Robaian, Asma Saleh Almeslet, Vikrant R. Patil, Saranya Varadarajan, Thodur Madapusi Balaji, Rod
    Journal of Personalized Medicine.2021; 11(7): 589.     CrossRef
  • Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
    Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
    PeerJ.2020; 8: e8740.     CrossRef
  • Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model


    Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Hassan Ganie, Aashiq Hussain Bhat, Showkat Ahmad Dar, Bilal Ahmad Reshi, Showkat Ahmad Ganie
    Journal of Inflammation Research.2020; Volume 13: 829.     CrossRef
  • The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
    Safaa Mohamed El Kotb, Dalia El-sayed El-ghazouly, Omnia Ameen
    Alexandria Journal of Medicine.2020; 56(1): 134.     CrossRef
  • Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation
    Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Soheila Adeli, Elham Harati, Hamid Reza Sadeghipour
    Respiratory Physiology & Neurobiology.2019; 270: 103265.     CrossRef
  • Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
    Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
    Pathogens.2019; 8(4): 229.     CrossRef
  • Amelioration ofEscherichia coli-induced endometritis with ascorbic acid in non-pregnant mouse models
    Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba-Idio, Kevin Odega, Osas Jim Eghianruwa
    American Journal of Reproductive Immunology.2018; 80(3): e12976.     CrossRef
The Association Between Serum GGT Level and Bone Mineral Density in Postmenopausal Women
Heung Yeol Kim, Eun Hee Kong
Kosin Med J. 2013;28(1):35-41.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.1.35
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  • 2 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

The aim of this study was to identify the relationship between serum gamma-glutamyltransferase (GGT) and bone mineral density (BMD) in postmenopausal women.

Methods

We evaluated 200 postmenopausal women who were visiting a health promotion center at a university hospital from January 2009 to December 2011. Their current medical diseases and medication history were collected through medical records. Basic physical examinations and laboratory tests were performed on all subjects.

Results

The levels of serum GGT within their normal range were positively correlated with waist circumference (P = 0.01), triglycerides (P <0.001), alkaline phosphatase (P = 0.009), and uric acid (P = 0.01). The serum GGT within their normal range were negatively associated with the femur neck BMD (P = 0.002). In adjusted analysis including age and body mass index, the BMD of the femur neck was more strongly associated with a high-normal serum GGT level among the postmenopausal women as compared with those with a low-normal serum GGT level (P = 0.02).

Conclusions

Serum GGT within its normal range is negatively correlated with the BMD in the femur neck among postmenopausal women. It can be useful for selecting a group that is at high risk for the bone fracture regardless of the underlying mechanism.

Citations

Citations to this article as recorded by  
  • The Role of Vitamin D in Menopausal Medicine
    Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
    Kosin Medical Journal.2016; 31(2): 97.     CrossRef
  • The Role of Vitamin D in Menopausal Medicine
    Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
    Kosin Medical Journal.2016; 31(2): 97.     CrossRef
Various Diet on Immune and Nutrition of Gastrointestinal Surgical Patients
Eun Hee Kong
Kosin Med J. 2011;26(2):127-133.   Published online December 1, 2011
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The Relationship with Metabolic Syndrome by Bone Mineral Density of Femur in Postmenopausal Women
Ho Seob Lihm, Eun Hee Kong
Kosin Med J. 2010;25(2):26-31.   Published online December 31, 2010
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Regulation of Piplartine on Apoptotic Death of Human Prostate Cancer Cells: Based on Microarray
Eun Hee Kong, Kwang Youn Kim, Sun Nyoung Yu, Sun Yi Lee, Soon Cheol Ann
Kosin Med J. 2010;25(2):117-122.   Published online December 31, 2010
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Relationship between Pulmonary Function and High Sensitive C-reactive Protein in Healthy Adults
Eun Hee Kong
Kosin Med J. 2009;24(2):92-97.   Published online December 31, 2009
  • 66 View
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Relationship with Serum Gamma-glutamyltransferase and Hypertension in Healthy Women
Eun Hee Kong
Kosin Med J. 2009;24(2):98-102.   Published online December 31, 2009
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Relationship with Metabolic Syndrome by Grade of Nonalcoholic Fatty Livers
Eun Hee Kong
Kosin Med J. 2009;24(2):103-108.   Published online December 31, 2009
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The Awarness Regarding Hypertension: Comparision of Hypertensive and Non-Hypertensive
Eun Hee Kong, Jong Soon Choi
Kosin Med J. 2008;23(4):137-142.   Published online December 31, 2008
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Development of Nutrition Screening Program for Hospital Inpatients
Su Mi Ahn, Ki Young Yoon, Yeon Myeong Sin, Kyung Hyun Choi, Geun Seung Lim, Moon Kyung Jang, Yun-Mi Song, Eun Hee Kong
Kosin Med J. 2008;23(2):29-35.   Published online June 30, 2008
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Health Literacy Regarding Educational Materials on Hypertension
Eun Hee Kong, Jong Soon Choi
Kosin Med J. 2007;22(1):81-88.   Published online June 30, 2007
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  • 2 Download
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The Relationship Between Initial Biochemical Bone Markers and Change of Bone Mineral Density in Post Menopausal Women with Hormone Therapy
Chi Heui Cho, Eun Hee Kong, Young Sik Choi, Yang Soo Kim, Heung Yeol Kim, Wan Kyu Eo, Ki Yeon Hong
Kosin Med J. 2007;22(1):212-219.   Published online June 30, 2007
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Awareness Regarding Hypertension on Hypertensive Patients in a Clinic of Internal Medicine
Eun Hee Kong, Jong Soon Choi
Kosin Med J. 2006;21(1):188-193.
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ANALYSIS OF REFERRAL CONTENTS IN OUTPATIENT DEPARTMENT OF FAMILY MEDICINE
Eun Hee Kong, Hyeong Soo Cha
Kosin Med J. 1999;14(1-2):81-89.
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KMJ : Kosin Medical Journal