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Dong Wa Koo 1 Article
Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms
Ji Hyun Lee, Hee Sang Tag, Geun Tae Kim, Min Jeong Kim, Seung Geun Lee, Eun Kyung Park, Dong Wa Koo
Kosin Med J. 2017;32(1):25-35.   Published online January 19, 2017
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Abstract PDFPubReader   ePub   

The role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator of cardiovascular risk, and analyzed whether vascular stiffness and FRS were affected by RF.


Two hundred forty-two subjects were included in this population-based study. RF was quantified with turbid immunometry using a cut-off of RF > 15 IU/ml to denote RF positivity. Information was then obtained on joint symptoms. Brachial-ankle PWV (baPWV) was measured using an automated device.


Of the 242 subjects, 15 were RF-positive. RF-positive subjects without joint symptoms had a higher baPWV and FRS than RF-negative subjects without joint symptoms, but the difference did not reach statistical significance. However, when we stratified the subjects into two groups (group A – high RF: RF ≥ 40 IU/ml; group B – low RF: RF < 40 IU/ml), group A showed significantly higher baPWV (1640.7 ± 179.6 ㎝/s vs. 1405.7 ± 225.7 ㎝/s, P= 0.008) and FRS (25.7 ± 4.87 vs. 11.8 ± 9.6, P< 0.001). Multiple regression analysis was used to examine potential confounders, and RF exhibited significant but modest effects on baPWV (adjusted R-squared = 0.038, P= 0.030).


In a sample of the general population without joint symptoms, higher levels of RF were associated with increased vascular stiffness, suggesting a pathophysiologic link between RF and endothelial dysfunction.


Citations to this article as recorded by  
  • Model-Based Design of Defense Cyber-Physical Systems to Analyze Mission Effectiveness and Network Performance
    Bong Gu Kang, Kyung-Min Seo, Tag Gon Kim
    IEEE Access.2019; 7: 42063.     CrossRef
  • Communication Analysis of Network-Centric Warfare via Transformation of System of Systems Model into Integrated System Model Using Neural Network
    Bong Gu Kang, Kyung-Min Seo, Tag Gon Kim
    Complexity.2018; 2018: 1.     CrossRef

KMJ : Kosin Medical Journal