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Chung Han Lee 15 Articles
Comparison of survival outcomes between modified radical mastectomy and breast conserving surgery in early breast cancer patients
Yoon Seok Kim, Dong Won Ryu, Chung Han Lee
Kosin Med J. 2016;31(1):19-29.   Published online February 4, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.1.19
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Abstract Objectives

Breast conserving surgery (BCS) for early breast cancer is now an accepted treatment, but there are controversies about its comparability with mastectomy. Thus, we investigated the survival outcomes who underwent BCS and modified radical mastectomy (MRM).

Methods

In this retrospective review, we analyzed the survival outcomes of 618 patients with early breast cancer who underwent two different surgery from January 2002 to December 2009. Postoperative pathologic difference, disease free survival period, overall survival period, recurrence pattern, recurrent rate and site were compared. In addition, preoperative patients data are also collected.

Results

Disease free survival period of MRM and BCS was 108.46 months and 80.82 months, respectively (P< 0.01). However, there was no significant correlation between overall survival period and operative methods (P= 0.67). In addition, recurrence pattern (P= 0.21), recurrent rate (P= 0.36) and site (P= 0.45, P= 0.09) were not associated with operative method.

Conclusions

In this study, we can suggest that early breast cancer patients could improve their disease free survival if they underwent MRM. So, when we operate high risk breast cancer patients, MRM could be considered for their disease free life. Further studies may be required to establish appropriate strategy of surgery for early breast cancer.

Peritoneal and gastric metastasis from invasive lobular breast carcinoma: a case report
Yoon Seok Kim, Eun Ae Jae, Dong Won Ryu, Chung Han Lee
Kosin Med J. 2015;30(1):87-92.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.87
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Abstract

Peritoneal and gastrointestinal metastasis from breast cancer is very rare. We report here a rare case of metastatic peritoneal and gastric cancer from breast lobular carcinoma after modified radical mastectomy. A 65-year old woman presented with anorexia, nausea, vomiting and dyspepsia for several weeks at 44 months after surgery. Radiologic study showed peritoneal metastasis, and surgical histopathology reported peritoneal and omental metastatic carcinoma. Esophagogastroduodenoscopic (EGD) biopsy also confirmed metastatic carcinoma originated from breast primary.

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  • Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
    Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
    Kosin Medical Journal.2015; 30(2): 103.     CrossRef
Outcome of Ductal Carcinoma in Situ in Patients with or Without p53 Mutations
Dong Won Ryu, Chung Han Lee
Kosin Med J. 2012;27(2):119-125.   Published online December 27, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.2.119
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

p53 is a tumor suppressor gene and plays an important role in the etiology of breast cancer. The aim of this study is to clarify clinical significance of p53 in Ductal Carcinoma in situ (DCIS), and discuss about survival effect.

Methods

The study subjects, 69 women with breast cancer, were a subset of patients operated from Jan 2005 to Dec 2006. We used a cutoff of 10% to distinguish between positive and negative p53 staining. The University of Southern California (USC)/Van Nuys Prognostic Index (VNPI) were compared with 2 categories of p53.

Results

The positivity of p53 was found in 20 patients (29.0%) in DCIS. And negativity of p53 was found in 49 patients (71.0%). And 15 patients (21.7%) had a low USC/VNPI score, 42 patients (60.9%) intermediate and 12 patients (17.4%) a high score. The positivity of p53 was correlated with high USC/VNPI (P = 0.001). The univariate analysis for prognostic factors associated with Disease Free Survival (DFS) revealed that patients with p53 positivity show shorter Disease Free Survival (DFS) than patients with p53 negativity (P = 0.013) and USC/VNPI was also statistically significant (P = 0.030).

Conclusions

According to our study, p53 was associated with high USC/VNPI. These findings suggest that p53 can be used to classify DCIS into at least two subtypes with differing prognoses.

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  • Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
    Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
    Kosin Medical Journal.2015; 30(2): 103.     CrossRef
Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer
Dong Won Ryu, Chung Han Lee
Kosin Med J. 2012;27(1):1-9.   Published online June 11, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.1.1
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumor or from its metastases. The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients may account for the different steps in the biologic progression of the disease. The detection of microscopic disease in patients with breast cancer is imperative to prognosis and can predict the efficacy of targeted treatments. In general, there are two main methods for their detection. These are based on cytometric and nucleic acid manipulation. Both methods generally require an enrichment step to increase sensitivity of the assay. This step is based on either detection of specific surface markers using immuno-selection and/or on morphological features, such as cell size or density. We review the methods of detecting CTCs, their prognostic implications, and opportunities to exploit the properties of CTCs to develop personalized therapy.

Citations

Citations to this article as recorded by  
  • Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
    Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
    Kosin Medical Journal.2015; 30(2): 103.     CrossRef
Clinical Usefulness of Cytokeratin 5/6 as an Immunohistochemical Marker to Predict Prognosis in Triple-negative Breast Cancer
Woo Sik Choi, Dong Won Ryu, Chung Han Lee
Kosin Med J. 2010;25(2):20-25.   Published online December 31, 2010
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Ki-67 index, Luminal B Type, and Prognosis of Patients with Breast Cancer
Dong Won Ryu, Woo Sik Choi, Chung Han Lee
Kosin Med J. 2010;25(1):59-65.   Published online June 30, 2010
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The Clinicopathologic Characteristics of HER-2 Type Breast Carcinoma
Dong Won Ryu, Chung Han Lee
Kosin Med J. 2009;24(2):157-152.   Published online December 31, 2009
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Hepatic Stem Cell Behavior after Injection of PGE1 on Proliferatively Impaired Regeneration Model
Sang Ho Lee, Chung Han Lee
Kosin Med J. 2007;22(1):140-146.   Published online June 30, 2007
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Clinical efficacy of sentinel lymph node biopsy using Tc-99m sulfur colloid and Methylene blue dye in breast cancer patients
Woo Sik Choi, Chang Wan Chun, Chung Han Lee
Kosin Med J. 2006;21(2):82-88.
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One Case of Pregnancy in a Terminal Stage Patient of Gastric Cancer
Chun June Lee, Chung Han Lee
Kosin Med J. 2004;19(1):165-168.
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Ultrastructural Changes of Sinusoid in N-diethylnitrosamine-induced Hepatic Fibrosis of Rat
Bang Hur, Kyung Won Kim, Young Ok Kim, Myung Hee Yoon, Chung Han Lee
Kosin Med J. 2004;19(1):26-33.
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Scanning Electron Microscopic Study for Morphological Changes of Microvasculature in Experimental Hepatic Fibrosis
Bang Hur, Myung Jong Lee, Bong Kwon Chun, Dong Hun Shin, Chung Han Lee
Kosin Med J. 2004;19(1):19-25.
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Investigation for the Alterations of 'Hepatic Progenitor Cells' during Hepatic Regeneration after Chemical Injury
Bang Hur, Myung Sun Park, Myung Hee Yoon, Chung Han Lee
Kosin Med J. 2004;19(1):9-18.
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Dendritic Cells as Adjuvants Therapy for Hepatocellular Carcinoma
Kyoung Hi Jeon, Dae Heui Lee, Chung Han Lee, Jae Sun Park
Kosin Med J. 2002;17(1):18-24.
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Male Breast Carcinoma Report of Three Cases and Literature Review
Chung Han Lee, Sung Do Lee, Jae Kwan Seo, Young Hoon Park, Hee Kyung Chang, Bang Hur, Man Ha Huh
The Journal of Kosin Medical College. 1988;4(1):123-128.
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KMJ : Kosin Medical Journal