Kosin Medical Journal

Byung-Kwon Ahn

3 Articles

Correlation of long interspersed element-1 open reading frame 1 and c-Met proto-oncogene protein expression in primary and recurrent colorectal cancers: Kyung-Yoon Jeon, Eun-Ji Ko, Hee-Kyung Chang, Seung-Hyun Lee, Byung-Kwon Ahn, Mee Sun Ock, Hee-Jae Cha; Kosin Med J. 2022;37(4):283-290. Published online December 22, 2022; DOI: https://doi.org/10.7180/kmj.22.106

1,836 View
27 Download
1 Citations

Background
Colorectal cancer is one of the most common cancers worldwide. Colorectal cancer that has recurred and metastasized to other organs also has a very poor prognosis. According to recent studies, the long interspersed element-1 (LINE-1) retrotransposon open reading frame (ORF) is located in the intron of the c-Met proto-oncogene, which is involved in cancer progression and metastasis, and regulates its expression. However, no study has compared the expression patterns of LINE-1 ORF1 and c-Met, which are closely related to cancer progression and metastasis, and their correlation in primary and recurrent cancers.
Methods
In the present study, we compared the expression patterns of LINE-1 ORF1 and c-Met in both primary and recurrent colorectal cancer tissues from 10 patients. Expression patterns and correlations between LINE-1 ORF1 and c-Met proto-oncogene proteins were analyzed by immunofluorescence staining using both LINE-1 ORF1 and c-Met antibodies.
Results
The expression patterns of LINE-1 ORF1 and c-Met showed significant individual differences, and the expression of both proteins was correlated in all colorectal cancer patients. However, the expression levels of LINE-1 ORF1 and c-Met were not significantly different between primary and recurrent colorectal cancers.
Conclusions
The protein expression levels of LINE-1 ORF1 and c-Met were correlated, but did not change significantly in cases of recurrent colorectal cancer in the same patient.

Citations

Citations to this article as recorded by

Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
Eun-Ji Ko, Do-Ye Kim, Min-Hye Kim, Hyojin An, Jeongtae Kim, Jee-Yeong Jeong, Kyoung Seob Song, Hee-Jae Cha
International Journal of Molecular Sciences.2024; 25(2): 833. CrossRef

Simultaneous Laparoscopy-Assisted Resection for Synchronous Colorectal and Gastric Cancer: Seung-Hyun Lee, Byung-Kwon Ahn, Sung-Uhn Baek; Kosin Med J. 2015;30(2):115-121. Published online January 20, 2015; DOI: https://doi.org/10.7180/kmj.2015.30.2.115

1,564 View
3 Download
3 Citations

Abstract PDF PubReader ePub

Abstract Objectives

The purpose of this study is to evaluate feasibility and safety of simultaneous laparoscopy-assisted resection for synchronous colorectal and gastric cancer.

Methods

From January 2001 to December 2013, a total of 29 patients underwent simultaneous resection for synchronous colorectal and gastric cancers. Medical records were reviewed, retrospectively.

Results

Eight patients (5 male) underwent laparoscopy-assisted resection (LAP group) and twenty one patients (17 male) underwent open surgery (Open group). In the both group, the mean age (65.2 vs. 63.7 years, p =0.481), body mass index (22.6 vs. 22.3, p = 0.896) was comparable, respectively. In LAP group, laparoscopy-assisted distal gastrectomy was performed for all eight patients. In Open group, subtotal gastrectomy with billroth I gastroduodenostomy was most common procedure (66.7%). The operation time, blood loss volume was similar between the two groups. Gas out was earlier (3.0 vs. 4.6 days p = 0.106), postoperative hospital stay was shorter (12.0 vs. 18.3 days, p = 0.245) in LAP group. The postoperative complications were an ileus, a wound seroma and a bile leakage in LAP group, pneumonia (10.0%), wound bleeding (5.0%) and leakage (5.0%) in Open group.

Conclusions

The simultaneous laparoscopy-assisted resection for synchronous colorectal cancer and gastric cancer is a feasible and safe procedure.

Citations

Citations to this article as recorded by

Minimally invasive treatment of multiple primary tumors of the gastrointestinal tract. Clinical observation
J. M. Madyarov, A. A. Filatov, A. E. Kulikov, Z. R. Rasulov, L. A. Shestakova, D. A. Chekini, I. N. Iurichev, V. V. Vereshchak, E. N. Puchkova, A. O. Rasulov, R. A. Rasulov
MD-Onco.2023; 3(3): 29. CrossRef
Simultaneous Treatment of Multifocal Gastric and Sigmoid Colon Carcinoma from Laparoscopic Access: A Case Report
Oleg V. Zaytsev, Ivan S. Ignatov, Aleksandr Yu. Ogorel'tsev, Sergey V. Bizyayev, Mariya A. Evsyukova, Yuliya B. Li, Maksim A. Yudin, Svetlana V. Snegur, Irina Yu. Bragina, Elena G. Korobova
I.P. Pavlov Russian Medical Biological Herald.2022;[Epub] CrossRef
Simultaneous Totally Laparoscopic Distal Gastrectomy and Anterior Resection for Synchronous Gastric and Colon Cancer
Beslen Goksoy
Cureus.2021;[Epub] CrossRef

The Safety of Elective Colorectal Surgery without Mechanical Bower Preparation: Chul-Min Lee, Seung-Hyun Lee, Byung-Kwon Ahn, Sung-Uhn Baek; Kosin Med J. 2012;27(2):105-110. Published online December 27, 2012; DOI: https://doi.org/10.7180/kmj.2012.27.2.105

1,264 View
1 Download

Abstract PDF PubReader ePub: Objectives
To reduce the risk of postoperative infectious complications and anastomotic leakage in colorectal surgery, preoperative mechanical bowel preparation (MBP) is performed routinely. The aim of this study was to evaluate the safety of primary anastomosis in elective colorectal surgery without MBP.
Methods
From Jan. 2005 to Dec. 2006, three hundred and seventy-nine patients of elective colorectal surgery with primary anastomosis were performed with MBP in 352 cases (Prep group) and without MBP in 24 cases (Non-prep group). For preoperative MBP, 4 liters of polyethylene glycol solution was administered. Postoperative infectious complications and other morbidity were reviewed with medical records and prospectively collected data.
Results
Demographic, clinical and treatment characteristics did not differ significantly between the two groups. The overall rate of abdominal infectious complications (wound infection, anastomotic leak) was 2.9 % in the Prep group and 9 % in the Non-prep group (P > 0.05). Anastomotic leak occurred in nine patients (2.6%) in the Prep group and one (4.5%) in the Non-prep group.
Conclusions
The incidence of infectious complications after elective colorectal surgery without MBP did not differ significantly compare to that with MBP. However, prospective, randomized clinical trial is needed to assess the safety of primary anastomosis in elective colorectal surgery without MBP.

Author index